The purpose of this work is realization of highly penetrative, high resolution, in vivo, real-time imaging. First, we will develop highly functional ultrashort pulse fiber lasers. Then, using the developed light source, we will develop multi-functional imaging system with the combination of highly penetrateive, high resolution optical coherence tomography (OCT)/ optical coherence microscopy (OCM) and multi-photon microscopy (MPM) at longer wavelength range. Especially, we will develop electrically controlled, high power, rapid wavelength tunable ultrashort pulse source, and we will realize automatically controlled high resolution OCT/OCM and MPM. Besides, we also aim to develop novel imaging technique via the collaboration with other teams by use of our light source technologies.
2019
Yamanaka M., Hayakawa N., Nishizawa N. (2019) Signal-to-background ratio and lateral resolution in deep tissue imaging by optical coherence microscopy in the 1700 nm spectral band. Sci. Rep., 9: 16041.
doi: 10.1038/s41598-019-52175-9.
Yamanaka M., Hayakawa N., Nishizawa N. (2019) High-spatial-resolution deep tissue imaging with spectral-domain optical coherence microscopy in the 1700 nm spectral band. J. Biomed. Opt., 24(7): 070502.
doi: 10.1117/1.JBO.24.7.070502.
Nishizawa N., Kawagoe H, Yamanaka M., Matsushima M., Mori K., Kawabe T. (2019) Wavelength Dependence of Ultrahigh-Resolution Optical Coherence Tomography Using Supercontinuum for Biomedical Imaging. IEEE Journal of Selected Topics in Quantum Electronics, 25: 7101115.
doi: 10.1109/JSTQE.2018.2854595.
西澤典彦 (2019) 超広帯域スーパーコンティニューム光源の開発, レーザー研究, 47 (10): 568-572.
2018
Nishizawa N., Niinomi T., Nomura Y., Jin L., and Ozeki Y. (2018) Octave Spanning Coherent Supercontinuum Comb Generation Based on Er-doped Fiber Lasers and Their Characterization, IEEE J. Select. Top. Quant. Electron., 24 (3).
doi:10.1109/JSTQE.2017.2776521.
Jin L., Sonnenschein V., Yamanaka M., Tomita H., Iguchi T., Sato A., Nozawa K., Yoshida K., Ninomiya S., Nishizawa N. (2018) 3.1–5.2 µm Coherent MIR Frequency Comb Based on Yb-doped Fiber Laser, IEEE J. Sel. Top. Quantum Electron., 24: 1-7.
doi:10.1109/JSTQE.2017.2759258.
2017
Kawagoe H., Yamanaka M., Nishizawa N. (2017) Axial resolution and signal-to-noise ratio in deep-tissue imaging with 1.7-µm high-resolution optical coherence tomography with an ultrabroadband laser source, J. Biomed. Opt., 22(8): 085002.
doi:10.1117/1.JBO.22.8.085002.
Jin L., Yamanaka M., Sonnenschein V., Tomita H., Iguchi T., Sato A., Oh-hara T., Nishizawa N. (2017) Highly coherent tunable mid-infrared frequency comb pumped by supercontinuum at 1 um Applied Physics Express, vol.10 012503.
doi:10.7567/APEX.10.012503.
Terabayashi R., Sonnenschein V., Tomita H., Hayashi N., Kato S., Jin L., Yamanaka M., Nishizawa N., Sato A., Nozawa K., Hashizume K., Oh-hara T. Iguchi T. (2017) Optical feedback in dfb quantum cascade laser for mid-infrared cavity ring-down spectroscopy, Hyepr. Inter., 238: 10.
doi:10.1007/s10751-016-1390-6.
