In photoacoustic imaging, it is possible to perform deep tissue imaging in living organisms and obtain cross-sectional images. Moreover, when paired with conventional ultrasound images, morphological information can be derived simultaneously with functional information by using an imaging agent. Similar to fluorescence imaging, photoacoustic imaging agents, if designed appropriately, will likely lead to the development of a wide range of specific biomolecules and agents that recognize the environment. In this study, we aim to develop a photoacoustic imaging agent that can detect specific disease states and molecules, by allowing it to form a self-assembling system efficiently, thereby changing the photoacoustic spectrum.
2018
Nakajima K., Kimura T., Takakura H., Yoshikawa Y., Kameda A., Shindo T., Sato K., Kobayashi H., Ogawa M. (2018) Implantable wireless powered light emitting diode (LED) for near-infrared photoimmunotherapy: device development and experimental assessment in vitro and in vivo. Oncotarget, 9 (28): 20048-20057.
doi: 10.18632/oncotarget.25068.
Ogawa M., Takakura H. (2018) In Vivo Molecular Imaging for Biomedical Analysis and Therapies. Anal. Sci., 34 (3): 273-281.
doi: 10.2116/analsci.34.273.
2017
Ogawa M., Tomita Y., Nakamura Y., Lee M.J., Lee S., Tomita S., Nagaya T., Sato K., Yamauchi T., Iwai H., Kumar A., Haystead T., Shroff H., Choyke P.L., Trepel J.B., Kobayashi H. (2017) Immunogenic cancer cell death selectively induced by near infrared photoimmunotherapy initiates host tumor immunity. Oncotarget, 8 (6): 10425-10436.
doi: 10.18632/oncotarget.14425.
Shimizu Y., Hanzawa H., Zhao Y., Fukura S., Nishijima K.I., Sakamoto T., Zhao S., Tamaki N., Ogawa M., Kuge Y. (2017) Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression. Mol. Imaging Biol., 19 (4): 531-539.
doi: 10.1007/s11307-016-1036-8.
