Michiyuki MATSUDA

Kyoto University Graduate School of Biostudies

Live imaging of intercellular communication

The cell fate within various tissues is determined by cell-cell adhesion and paracrine factors. To understand such cell-cell signaling in live tissues, we need to visualize the intercellular communication in the absence and presence of various perturbations. In this project, we will improve our techniques to visualize the activities of protein kinases and small GTPases in living mice, so that we can detect the signaling activities with higher sensitivity and in near-infrared wavelength fluorescence. We will also develop chemical compounds that could modulate the activities of intracellular signaling molecules. With this approaches combined, we will shed new light to the regulatory mechanism of cellular response and cell fate.